Surface Property Modification of Hyaluronic Acid Scafold and Loading of Mesenchymal Stem Cells on Hyaluronic Acid Scafold: A Mini Review

Background and aim: Hyaluronic acid (HA) scaffolds have emerged as versatile biomaterials for tissue engineering and regenerative medicine due to their biocompatibility and tunable properties. However, optimizing their surface properties is essential to enhance cell adhesion, proliferation, and differentiation, which are crucial for successful tissue regeneration. This review aims to provide an overview of the methods and strategies employed to modify the surface properties of HA scaffolds.
Methods: A comprehensive literature search was conducted to gather relevant studies on surface property modification of HA scaffolds. Various techniques, including chemical modifications, cross-linking, nanoparticle integration, and bioactive coatings, were analyzed for their effectiveness in altering the surface characteristics of HA scaffolds. Additionally, we explored the impact of these modifications on mesenchymal stem cells loading and proliferation.
Results: The review highlights a range of methods used to modify the surface properties of HA scaffolds, each offering unique advantages and limitations. Chemical modifications enable precise control over surface chemistry, while cross-linking enhances mechanical stability. Integration of nanoparticles imparts additional functionalities, and bioactive coatings promote specific cellular responses. These modifications have demonstrated improved stem cells adhesion, proliferation, and differentiation, ultimately enhancing tissue regeneration potential.
Conclusion: Surface property modification of hyaluronic acid scaffolds is a key strategy in tissue engineering. Various methods offer precise control over surface properties, enhancing cell interactions and tissue regeneration potential. Future research should focus on multifunctional HA scaffolds, advancing tissue engineering possibilities.